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2013年
（論文）
Goto M, Ishikawa Y, Sugimoto M, Furuichi Y.
Werner syndrome: a changing pattern of clinical manifestations in Japan (1917~2008). Biosci Trends. 7, 13-22. 2013.
Sanada S, Futami K, Terada A, Yonemoto K, Ogasawara S, Akiba J, Yasumoto M,
Sumi A, Ushijima K, Kamura T, Furuichi Y, Yano H .
RECQL1 DNA Repair Helicase: A Potential Therapeutic Target and a
Proliferative Marker against Ovarian Cancer.
PLoS One. 8, e72820. 2013.
2012年
（論文）
Miyamoto M, Furuichi Y, Komiyama T.
The high-osmolarity glycerol- and cell wall integrity-MAP kinase pathways of Saccharomyces cerevisiae are involved in adaptation to the action of killer toxin HM-1. Yeast. 29, 475-485. 2012.
Goto M, Sugimoto K, Hayashi S, Ogino T, Sugimoto M, Furuichi Y, Matsuura M,
Ishikawa Y, Iwaki-Egawa S, Watanabe Y.
Aging-associated inflammation in healthy Japanese individuals and patients with Werner syndrome. Exp Gerontol. 47, 936-939. 2012.
Kubota N, Inayoshi Y, Satoh N, Fukuda T, Iwai K, Tomoda H, Kohara M, Kataoka K,
Shimamoto A, Furuichi Y, Nomoto A, Naganuma A, Kuge S.
HSC90 is required for nascent hepatitis C virus core protein stability in yeast cells. FEBS Lett. 586, 2318-2325. 2012.
De S, Kumari J, Mudgal R, Modi P, Gupta S, Futami K, Goto H, Lindor NM, Furuichi
Y, Mohanty D, Sengupta S.
RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress. J Cell Sci. 125, 2509-2522. 2012.
Takada-Watanabe A, Yokote K, Takemoto M, Fujimoto M, Irisuna H, Honjo S, Futami
K, Furuichi Y, Saito Y.
A case of Werner syndrome without metabolic abnormality: implications for the early pathophysiology. Geriatr Gerontol Int. 12, 140-146. 2012.
2011年
（論文）
Kabir ME, Karim N, Krishnaswamy S, Selvakumar D, Miyamoto M, Furuichi Y, Komiyama T.
Peptide derived from anti-idiotypic single-chain antibody is a potent antifungal
agent compared to its parent fungicide HM-1 killer toxin peptide. Appl Microbiol Biotechnol. 92, 1151-1160. 2011.
Rahman MM, Kabir ME, Krishnaswamy S, Miyamoto M, Furuichi Y, Komiyama T.
New avenues for phage-display library to produce a Cryptococcus-specific anti-idiotypic antibody of HM-1 killer toxin. J Mol Recognit. 24, 631-641. 2011.
Sugimoto M, Furuichi Y, Ide T, Goto M.
Involvement of WRN helicase in immortalization and tumorigenesis by the telomeric crisis pathway (Review). Oncol Lett. 2, 609-611. 2011.
Kabir ME, Krishnaswamy S, Miyamoto M, Furuichi Y, Komiyama T.
An altered camelid-like single domain anti-idiotypic antibody fragment of HM-1 killer toxin: acts as an effective antifungal agent. Appl Microbiol Biotechnol. 90, 553-564. 2011.
Krishnaswamy S, Kabir ME, Rahman MM, Miyamoto M, Furuichi Y, Komiyama T.
Isolation and characterization of recombinant single chain fragment variable anti-idiotypic antibody specific to Aspergillus fumigatus membrane protein. J Immunol Methods. 366, 60-68. 2011.
Arai A, Chano T, Futami K, Furuichi Y, Ikebuchi K, Inui T, Tameno H, Ochi Y, Shimada T, Hisa Y, Okabe H.
RECQL1 and WRN Proteins Are Potential Therapeutic Targets in Head and Neck Squamous Cell Carcinoma. Cancer Res. 71, 4598-4607. 2011.
（総説）
二見和伸、古市泰宏
RecQヘリカーゼを標的とするsiRNA創薬, 医学のあゆみ, 238, 553-559, 2011.
2010年
（論文）
Kataoka K, Kono Y, Sugtimoto M, Furuichi Y, Shichiri M, Tanaka Y.
Hepatocyte-protective and anti-oxidant effects of rifampicin on human chronic hepatitis C and murine acute hepatocyte disorder. Exp Ther Med. 1, 1041. 2010.
Futami K, Ogasawara S, Goto H, Yano H, Furuichi Y.
RecQL1 DNA repair helicase: A potential tumor marker and therapeutic target against hepatocellular carcinoma. Int J Mol Med. 25, 537. 2010.
（総説）
二見和伸、古市泰宏
RNA工学を用いた医薬品への挑戦〜siRNAを中心として〜, 医薬品医療機器レギュラトリーサイエンス, 41, 19-26, 2010. （SummaryのPDF ）
2009年
（論文）
Kabir
ME, Krishnaswamy S, Miyamoto M, Furuichi Y, Komiyama T.
An
improved phage-display panning method to produce an HM-1 killer toxin
anti-idiotypic antibody. BMC Biotechnol.
9, 99. 2009. [Epub ahead of print]
Krishnaswamy
S, Kabir ME, Miyamoto M, Furuichi Y, Komiyama T.
Cloning
antifungal single chain fragment variable antibodies by phage display and
competitive panning elution. Anal
Biochem. 395, 16-24, 2009.
Abe
T, Goda K, Futami K, Furuichi Y.
Detection
of siRNA administered to cells and animals by using a fluorescence intensity
distribution analysis polarization system. Nucleic Acids Res. 37,
e56, 2009.
Futami
K, Furuichi Y.
Quantitation
of full-size small interfering RNA by tailing with terminal deoxynucleotidyl
transferase and reverse transcription-polymerase chain reaction analysis. Anal
Biochem. 385, 386-388, 2009.
Iso T,
Futami K, Iwamoto T, Furuichi Y.
Effects
of estrogenic agents 17β-Estradiol
(E2) and bisphenol A on the expression of RecQ DNA helicases in mammary
tumorMCF-7 cells. J Health Sci. 55,
119-124, 2009.
（総説）
古市泰宏
「【追悼】 三浦謹一郎先生を偲んで」 蛋白質核酸酵素, 12月号, Vol. 54, 2009.
二見和伸、古市泰宏
「遺伝子医学MOOK15号〜最新RNAと疾患研究」〜第3章RNA研究から臨床へ-4；RecQ ヘリカーゼを標的とするsiRNA創薬, 中村義一編, 株式会社メディカルドゥ, 2009.
二見和伸、古市泰宏
「バイオ医薬の開発技術とシーズ」〜23章DNAヘリカーゼを標的としたRNAi型癌治療薬への開発, 山本重夫編, シーエムシー出版, 222-234, 2009.
古市泰宏
「siRNA医薬による肝癌の分子標的治療」 肝胆膵, 58(3): 395-402, 2009.
（学会発表など）
古市泰宏
「癌治療に向けて、DNA修復ヘリカーゼを標的とするsiRNA創薬」 財団法人高松宮妃癌研究基金第40回国際シンポジウム, 2009, 東京
Ogasawara S, Akiba J, Nakashima O, Futami K,
Furuichi Y, Yano H.
Expression of RecQL1 helicase in hepatocellular carcinoma, International Liver Cancer
Association (ILCA) 3rd annual conference, 2009, Milan
小笠原幸子、秋葉純、中島収、真田咲子、谷川健、安元真希子、古市泰宏、二見和伸、矢野博久
肝細胞癌におけるRecQL1ヘリカーゼ発現の臨床病理学的検討, 第45回日本肝臓学会総会, 2009, 神戸
小笠原幸子、秋葉純、中島収、真田咲子、守屋普久子、谷川健、安元真希子、古市泰宏、二見和伸、矢野博久
肝細胞癌におけるRecQL1ヘリカーゼ発現の臨床病理学的検討, 日本病理学会 第98回総会, 2009, 京都
2008年
（論文）
Hirose
K, Wakashin H, Oki M, Kagami S, Suto A, Ikeda K, Watanabe N, Iwamoto I,
Furuichi Y, Nakajima H.
GS143,
an IkappaB ubiquitination inhibitor, inhibits allergic airway inflammation in
mice. Biochem Biophys Res Commun. 374, 507-511, 2008.
Futami
K, Kumagai E, Makino H, Sato A, Takagi M, Shimamoto A, Furuichi Y.
Anticancer
activity of RecQL1 helicase siRNA in mouse xenograft models. Cancer Sci. 99, 1227-1236, 2008.
Izumikawa
K, Yanagida M, Hayano T, Tachikawa H, Komatsu W, Shimamoto A, Futami K,
Furuichi Y, Shinkawa T, Yamauchi Y, Isobe T, Takahashi N.
Association
of human DNA helicase RecQ5beta with RNA polymerase II and its possible role in
transcription. Biochem J. 413, 505-516, 2008.
Futami
K, Ishikawa
Y, Goto M, Furuichi Y, Sugimoto M.
Role
of WRN helicase in carcinogenesis and in resistance by cancer cells to
genotoxins. Cancer Sci. 99, 843-848, 2008.
Nakajima
H, Fujiwara H, Furuichi Y, Tanaka K, Shimbara N.
A
novel small-molecule inhibitor of NF-kappaB signaling. Biochem Biophys Res Commun. 368,
1007-1013, 2008.
Futami
K, Kumagai E, Makino H, Goto H, Takagi M, Shimamoto A, Furuichi Y.
Induction
of mitotic cell death in cancer cells by small interference RNA suppressing the
expression of RecQL1 helicase. Cancer
Sci. 99, 71-80, 2008.
（総説）
二見和伸、古市泰宏
��.「老化の機序解明とその対策」〜7.「早老症とその機序を利用した抗癌剤創薬」, Surgery
Frontier, Vol.15, No.4, 48(394)-54(400), 2008.
二見和伸、古市泰宏
「RecQヘリカーゼ群によるゲノム維持と疾患、そして創薬への応用」, 細胞工学, Vol. 27, No. 10, 1020-1026, 2008.
二見和伸、古市泰宏
「がんの分子標的治療」〜15章がん治療へ向けたRNA創薬, 鶴尾隆編, 南山堂, 90-97, 2008.
2007年
（論文）
Futami
K, Takagi M, Shimamoto A, Sugimoto M, Furuichi Y.
Increased
chemotherapeutic activity of camptothecin in cancer cells by siRNA-induced
silencing of WRN helicase. Biol Pharm Bull. 30, 1958-1961, 2007.
Futami
K, Shimamoto A, Furuichi Y.
Mitochondrial
and Nuclear localization of human Pif1 helicase. Biol Pharm Bull. 30, 1685-1692, 2007.
Oishi
M, Nagasaki Y, Nishiyama N, Itaka K, Takagi M, Shimamoto A, Furuichi Y, Kataoka
K.
Enhanced
growth inhibition of hepatic multicellular tumor spheroids by lactosylated
poly(ethylene glycol)-siRNA conjugate formulated in PEGylated polyplexes. ChemMedChem. 2, 1290-1297, 2007.
Iso
T, Futami K, Iwamoto T, Furuichi Y.
Modulation
of the Expression of Bloom Helicase by Estrogenic Agents. Biol Pharm Bull. 30, 266-271, 2007.
（総説）
二見和伸、古市泰宏
「がん治療へ、siRNA医薬への期待」ヒューマンサイエンス（会報）, Vol 18, No.
6, 14-17, 2007.
（学会発表など）
二見和伸、高木基樹、嶋本顕、杉本正信、古市泰宏
WRNヘリカーゼのサイレンシングによる癌細胞のカンプトテシン感受性向上, BMB2007, 横浜
2006年
（論文）
Shibata
S, Sasaki M, Miki T, Shimamoto A, Furuichi Y, Katahira J, Yoneda Y.
Exportin-5
orthologues are functionally divergent among species. Nucleic Acids Res. 34,
4711-4721, 2006.
Woo
LL, Futami K, Shimamoto A, Furuichi Y, Frank KM.
The
Rothmund-Thomson Gene, RECQL4, localized to the nucleolus in response to
oxidative stress. Exp Cell Res. 312, 3443-3457, 2006.
Selvakumar
D, Karim N, Miyamoto M, Furuichi Y, Komiyama T.
Recombinant
single-chain anti-idiotypic antibody: an effective fungal beta-1,3-glucan
synthase inhibitor. Biol Pharm Bull. 29,1848-1853, 2006.
Selvakumar
D, Miyamoto M, Furuichi Y, Komiyama T.
Inhibition
of fungal beta-1,3-glucan synthase and cell growth by HM-1 killer toxin
single-chain anti-idiotypic antibodies. Antimicrob
Agents Chemother. 50, 3090-3097,
2006.
Goto
M, Okawa-Takatsuji M, Aotsuka S, Nakai H, Shimizu M, Goto H, Shimamoto A,
Furuichi Y.
Significant
elevation of IgG anti-WRN (RecQ3 RNA/DNA helicase) antibody in systemic
sclerosis. Mod Rheumatol. 16, 229-234, 2006.
Kawabe
Y, Seki M, Yoshimura A, Nishino K, Hayashi T, Takeuchi T, Iguchi S, Kusa Y,
Ohtsuki M, Tsuyama T, Imamura O, Matsumoto T, Furuichi Y, Tada S, Enomoto T.
Analyses
of the interaction of WRNIP1 with Werner syndrome protein (WRN) in vitro and in
the cell. DNA Repair (Amst). 5, 816-828, 2006.
Selvakumar
D, Miyamoto M, Furuichi Y, Komiyama T.
Inhibition
of beta-1,3-glucan synthase and cell growth of Cryptococcus species by
recombinant single-chain anti-idiotypic antibodies. J Antibiot (Tokyo). 59, 73-79, 2006.
Selvakumar
D, Zhang QZ, Miyamoto M, Furuichi Y, Komiyama T.
Identification
and characterization of a neutralizing monoclonal antibody for the epitope on
HM-1 killer toxin. J Biochem. 139, 399-406, 2006.
Iso
T, Watanabe T, Iwamoto T, Shimamoto A, Furuichi Y.
DNA
damage caused by bisphenol A and estradiol through estrogenic activity. Biol Pharm Bull. 29, 206-210, 2006.
（総説）
高木基樹、佐藤あゆみ、嶋本 顕、古市泰宏
「遺伝子医学MOOK4号〜RNAと創薬」〜RecQヘリカーゼを標的とした制癌剤治療, 中村義一編, 株式会社メディカルドゥ, 2006.
（学会発表など）
安部隆史、合田和史、二見和伸、古市泰宏
蛍光偏光解析法によるsiRNAの生体内濃度測定法の開発, 第17回アンチセンスシンポジウム, 2006, 金沢
二見和伸、熊谷栄美、牧野弘、伊藤千絵、古市泰宏
RecQL1-siRNAによる抗癌剤開発, 第17回アンチセンスシンポジウム, 2006, 金沢
村田絵里子、多田周右、二見和伸、古市泰宏、関政幸、榎本武美
RecQL1 siRNAの処理によるがん細胞死, 日本薬学会東北支部会 第45回大会, 2006, 仙台
小野愛美、小西由紀、永田佳代子、高部祥子、上杉晴一、三好達也、河合文隆、二見和伸、嶋本顕、片平正人
hnRNP
A1/hnRNP D0タンパク質とテロメア長の関係, 日本分子生物学会2006フォーラム, 2006, 名古屋
2005年
（論文）
Sawada
K, Noda K, Nakajima H, Shimbara N, Furuichi Y, Sugimoto M.
Differential
cytotoxicity of anticancer agents in pre- and post-immortal lymphoblastoid cell
lines. Biol Pharm Bull. 28, 1202-1207, 2005.
Miyamoto
M, Han GD, Kimura T, Furuichi Y, Komiyama T.
Alanine-scanning
mutagenesis of HM-1 killer toxin and the essential residues for killing
activity. J Biochem. 137, 517-22. 2005.
Takahashi
M, Okada J, Ito K, Hashimoto M, Hashimoto K, Yoshida Y, Furuichi Y, Ohta Y,
Mishiro S, Gemma N.
Construction
of an electrochemical DNA chip for simultaneous genotyping of single nucleotide
polymorphisms. Analyst. 130, 687-93. 2005.
Sengupta
S, Shimamoto A, Koshiji M, Pedeux R, Rusin M, Spillare EA, Shen JC, Huang LE,
Lindor NM, Furuichi Y, Harris CC.
Tumor
suppressor p53 represses transcription of RECQ4 helicase. Oncogene 24, 1738-48,
2005.
Futami
K, Goto H, Shimamoto A, Watanabe T, Furuichi Y.
Quantitative
analysis of Werner helicase activity by using the single-molecule fluorescence
detection system MF10S. Biol Pharm Bull.
28, 9-12, 2005.
（総説）
嶋本顕、二見和伸、古市泰宏
「ゲノムの安定化機構 – 老化研究から癌治療への応用」, Biotherapy 19, 390-397, 2005.
杉本正信、井出利憲、古市泰宏
「EBVによるB細胞の不死化・癌化――定説の否定」, 蛋白質核酸酵素, 3月号, Vol.
50, 283-288, 2005.
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